Which organelle is primarily responsible for the detoxification of lipid-soluble drugs and toxins in liver cells?
A. Smooth Endoplasmic Reticulum
B. Rough Endoplasmic Reticulum
C. Lysosome
D. Golgi Apparatus
Answer: Option A
Solution (By JKExamLibrary)
The Smooth Endoplasmic Reticulum (SER) in liver hepatocytes contains enzymes like cytochrome P450 that detoxify lipid-soluble drugs, metabolic waste, and toxins by making them water-soluble for excretion. Rough ER is involved in protein synthesis, the Golgi apparatus in packaging and secretion, and lysosomes in intracellular digestion. Exam tip: SER is abundant in liver and adrenal cortex cells.
Explanation:
Vaccination introduces antigens (weakened or killed pathogens) to stimulate the body's own immune system to produce antibodies and memory cells without causing disease. This is artificial active immunity. Natural active immunity is acquired by recovering from infection. Artificial passive immunity is direct administration of antibodies (e.g., antiserum). Natural passive immunity is transfer of maternal antibodies to fetus.
Explanation:
Glucagon, secreted by alpha cells of the pancreas when blood glucose is low, binds to liver receptors activating glycogenolysis (glycogen → glucose) and gluconeogenesis. Insulin promotes glycogenesis (glucose → glycogen). Thyroxine affects metabolism, somatostatin inhibits both insulin and glucagon.
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