The 'Bohr effect' in human physiology describes the shift in the oxygen dissociation curve of hemoglobin due to changes in: MCQ with Answer and Explanation

The 'Bohr effect' in human physiology describes the shift in the oxygen dissociation curve of hemoglobin due to changes in:
A. Concentration of 2,3-BPG only
B. Partial pressure of CO2 and H+ concentration (pH)
C. Temperature only
D. Partial pressure of O2 only
Answer: Option B
Solution (By JKExamLibrary)
The Bohr effect describes how an increase in the partial pressure of CO2 (pCO2) or a decrease in pH (increase in H+ concentration) reduces hemoglobin's affinity for oxygen, shifting the oxygen dissociation curve to the right. This facilitates the unloading of oxygen in metabolically active tissues where CO2 and acid levels are high. The reverse occurs in the lungs, enhancing oxygen loading.

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