The 'Hormone Somatostatin' is a universal inhibitor. In the gastrointestinal tract, it inhibits the release of almost all other GI hormones. It is secreted by the:
A. Delta (D) cells of the pancreatic islets and the D cells of the GI mucosa
B. G cells of the stomach
C. I cells of the duodenum
D. S cells of the duodenum
Answer: Option A
Solution (By JKExamLibrary)
Somatostatin is a powerful, universal inhibitory peptide hormone. In the gastrointestinal tract and pancreas, it is secreted by the Delta (D) cells of the pancreatic islets and the D cells of the gastric and intestinal mucosa. Its primary role in the GI tract is to act as a paracrine inhibitor, suppressing the release of almost all other gastrointestinal hormones, including gastrin, secretin, cholecystokinin (CCK), vasoactive intestinal peptide (VIP), and gastric inhibitory peptide (GIP). It also inhibits gastric acid secretion, pancreatic enzyme secretion, and intestinal motility, acting as a 'brake' on the digestive system.
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