The juxtaglomerular apparatus (JGA) in the kidney is formed by the modification of cells in the: MCQ with Answer and Explanation

The juxtaglomerular apparatus (JGA) in the kidney is formed by the modification of cells in the:
A. Proximal convoluted tubule and descending limb of Henle
B. Distal convoluted tubule and afferent arteriole
C. Bowman's capsule and glomerulus
D. Collecting duct and efferent arteriole
Answer: Option B
Solution (By JKExamLibrary)
The juxtaglomerular apparatus (JGA) is a specialized structure where the distal convoluted tubule (DCT) comes into contact with the afferent arteriole. It consists of juxtaglomerular cells (modified smooth muscle cells in the afferent arteriole that secrete renin), macula densa cells (modified DCT cells that sense NaCl concentration), and extraglomerular mesangial cells. It plays a crucial role in regulating blood pressure and glomerular filtration rate via the renin-angiotensin-aldosterone system.

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