The 'Hormone Glucagon-like Peptide-1' (GLP-1) is an incretin hormone secreted by the L cells of the distal intestine. Its primary functions include:
A. Stimulating glucose-dependent insulin release, inhibiting glucagon release, slowing gastric emptying, and promoting satiety
B. Stimulating gastric acid secretion
C. Increasing intestinal motility
D. Inhibiting insulin release
Answer: Option A
Solution (By JKExamLibrary)
Glucagon-like Peptide-1 (GLP-1) is a powerful incretin hormone secreted by the L cells of the distal small intestine (ileum) and colon in response to food ingestion. Its primary functions are highly beneficial for glucose homeostasis: it stimulates insulin secretion from the pancreas in a glucose-dependent manner (only when blood glucose is high), inhibits glucagon secretion, slows down gastric emptying (allowing more time for nutrient absorption), and acts on the brain to promote satiety and reduce food intake. GLP-1 analogs (like exenatide) are used as drugs to treat type 2 diabetes.
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