The 'Hershey-Chase' experiment in 1952 used radioactive isotopes to prove that DNA is the genetic material of bacteriophages. They used: MCQ with Answer and Explanation

In 1952, Alfred Hershey and Martha Chase conducted the famous blender experiment to confirm that DNA is the genetic material of the T2 bacteriophage. They used radioactive sulfur (35S) to label the protein coat (capsid) of the phage, as sulfur is present in amino acids (methionine, cysteine) but not in DNA. They used radioactive phosphorus (32P) to label the DNA, as phosphorus is in the DNA backbone but not in proteins. After infection and blending, they found that only 32P (DNA) entered the bacterial cell to produce new phages, proving DNA is the genetic material.