The 'Hormone Vasoactive Intestinal Peptide' (VIP) is a neuropeptide found in the central nervous system and the gut. Its primary functions in the gut include:
A. Stimulating intestinal water and electrolyte secretion, relaxing intestinal smooth muscle, and stimulating pancreatic bicarbonate secretion
B. Stimulating gall bladder contraction
C. Stimulating gastric acid secretion
D. Inhibiting intestinal motility
Answer: Option A
Solution (By JKExamLibrary)
Vasoactive Intestinal Peptide (VIP) is a 28-amino acid neuropeptide that acts as a neurotransmitter and a hormone. In the gastrointestinal tract, its primary functions are stimulatory and relaxant: it stimulates the secretion of water and electrolytes into the intestinal lumen (acting as a secretagogue), relaxes the smooth muscle of the gut (including the lower esophageal sphincter, stomach, and gall bladder), and stimulates the pancreas to secrete a bicarbonate-rich juice. It also causes vasodilation in the gut. Excessive VIP secretion can lead to severe watery diarrhea (as in VIPoma).
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